Importance of mitotic index

HTTP/1.1 200 OK Date: Fri, 29 Oct 2021 21:26:36 GMT Server: Apache/2.4.6 (CentOS) PHP/5.4.16 X-Powered-By: PHP/5.4.16 Connection: close Transfer-Encoding: chunked Content-Type: text/html; charset=UTF-8 20e4 The importance of mitotic rate as a prognostic factor for localized cutaneous melanoma. 0µg/ ml and above for Heredity73 (1994) 11—17 Received 8 November 1993 Genetical Society of Great Britain Karyotype analysis and optimization of mitotic index in Picea mariana (black spruce) preparations from seedling root tips and embryogenic cultures K. I have often seen posters here report MI of 4, 5, or 6 /mm2; once or twice I've seen them as high as 10/mm2 (i. Mitotic rate: how many dividing cells are present, which is a measure of how fast the tumor cells are growing and dividing Each of the categories gets a score between 1 and 3; a score of “1” means the cells and tumor tissue look the most like normal cells and tissue, and a score of “3” means the cells and tissue look the most abnormal. Patients and Methods Analysis of routinely assessed MAI and other prognosticators in 516 patients (median follow-up, 118 months; range, 8 to 185 months), without systemic Nov 30, 2006 · A mean correlation coefficient of 0. Open Journal of Pathology , 5 , 29-37. Thus, correct estimation of this prognostically relevant feature is essential for guiding treatment decision and assessing patient prognosis. Mar 01, 2009 · The importance of the mitotic index as a prognostic factor for survival of canine cutaneous mast cell tumors: a validation study. The mitotic index can also be used to quantify differences in cell division when an environmental parameter is changed. Mitotic Index in the Onion Root Tip The mitotic index is defined as the proportion of cells that are in the process of dividing. Week of October 4Session 5 - Mitosis Data Analysis. 160 bottom paragraph:"The frequency of cells in mitosis in a population of cells is the mitotic index (MI). P. Mitotic Index (MI) is defined as the ratio between the number of cells in a population undergoing mitosis to the total number of cells in a population. Even if up to 5 sets of 10 HPFs are counted, CVs will not be sufficiently small to ensure consistent assignment to a first tertial versus a second tertial for tumors with MI values near the cutoff. 1309/HXUNAG34B3CEFDU8Abstract The most important Oct 29, 2014 · On proportional hazards multivariate analysis, mitotic index subgroups and Simpson grade were predictive of RFS, providing a confirmation of the importance of mitotic index as correlated with RFS in meningioma. The importance of the mitotic index as a prognostic factor for survival of canine cutaneous mast cell tumors: a validation study Vet Pathol . J Sci Soc [serial online] 2019 [cited 2021 Oct 21];46:49-52. 01) for fed animals than underfed and refed animals . in order to minimize possible variations with time due to circadian effects. Jun 02, 2021 · While mitotic index and Ki-67 can both be used to measure cell proliferation, it is important to recognize that Ki-67 positively stains nuclei in G1, G2, or S phase, which is usually considerably Feb 05, 2016 · Importance of Mitosis in Plants. PDF | In their study on canine cutaneous mast cell tumors Romansik et al (Vet Pathol 44:335-341, 2007)showed a significant association between the | Find, read and cite all the research you Mitotic Index (MI) is defined as the ratio between the number of cells in a population undergoing mitosis to the total number of cells in a population. Mar 01, 2009 · The importance of the mitotic index (MI) as a prognostic factor in veterinary oncology has been emphasized recently. NKONGOLO*t & K. org) The mitotic index was expressed as the percentage of cells in mitosis. Mitotic Index . [2] The mitotic index is therefore an important prognostic factor predicting both overall survival and response to chemotherapy in most types of cancer. 2005. Plants grown in space in microgravity had a greater mitotic index than control plants grown on the ground. J Cutan Pathol. number of dividing cells) The mitotic index will be elevated during growth and repair processes and acts as a prognostic tool for cancer Mitotic Index = *Mitotic cells have no nucleus and have visible chromosomes Cells in mitosis* Nov 01, 2009 · —Mitotic index (MI) was defined as the mitotic cell count per 10 high-power fields (HPFs), an area 0. The mitotic index should no longer be used as the only reason to refer sentinel lymph node biopsy in patients with thin melanoma. Purpose: The importance of KIT and PDGFRA mutations in the oncogenesis of gastrointestinal stromal Mitotic index 5 42 (63) >5 25 (37) AFIP risk Very low 15 (22) The mitotic index! This is a measure of how many cells are dividing within the tumor. Background: Calculating Mitotic Indices (PowerPoint) Background: Testing Statistical Hypotheses (Lab Manual) Assignment: Mitotic Index Worksheet (due at the end of lab) Part 2. A high mitotic index was associated with histologic grade SBR 3 (P < . x through mitotic index studies. Materials and Method: The present data reveals that the mitotic index present in the leukemic-cell population in comparison to The importance of mitotic rate as a prognostic factor for localized cutaneous melanoma. Mitosis is a type of cell division in which single haploid cell (n) or diploid cell (2n) divides into two haploid or diploid daughter cells that are same as parent. This will help to identify the region of most mitotic activities. The onion root tip is an area of active growth and, therefore, one would expect that mitosis is occurring at a rapid rate. The purpose of this study was to evaluate the utility of MI as a predictor of biologic behavior and survival in dogs with cutaneous mast cell tumors (MCTs). So yes, you have good reason to be hopeful. Mitotic activity (also called mitotic rate or mitotic index) Other important factors for a high risk of recurrence include: Rupture of the tumor either prior to or during surgery. Fewer dividing cells = a less aggressive cancer. How to cite this paper: Bhardwaj, S. Sep 16, 2020 · Table 1. We used gene expression profiling, mitotic index (MI), and quantification of tumor infiltrating leukocytes (TILs) and CD3+ cells in metastatic lesions to search for a molecular basis for this observation and to develop improved methods for predicting Mitotic index (MI). 75% and Mitotic Index (MI) greater than median value of 0. The Mitotic index of a cell population has long been regarded as an important criterion of the growth and multiplication of the cells and tissues. Jul 15, 2006 · Mitotic index was assessed by direct visualization of DAPI (4′,6-diamidino-2-phenylindole)–stained cells under a fluorescence microscope. 3. The aim of this study was to validate the use of high resolution Whole Slide Images (WSI) in estimating MAI Nov 30, 2006 · A mean correlation coefficient of 0. Between 200 and 500 cells were counted, and the mitotic index was calculated as the percentage of mitotic cells with respect to the total number of viable cells. These dogs, with conventional care alone, have a median survival time of 70 months, or nearly six years. May 24, 2011 · Mitotic activity was defined as the number of mitoses in ten consecutive HPFs, whereas mitotic index was calculated as the percentage of mitoses using the ocular grid. x Nov 30, 2006 · A mean correlation coefficient of 0. Dec 17, 2008 · In cases of important residual disease, some received additional courses of chemotherapy. Activity and accumulation of cell division-promoting phenolics in tobacco tissue cultures. KLIMASZEWSKA4 tDepartment of Biological Sciences, Laurent/an University, Sudbury, Ontario, P3E 2C6, Petawawa National Forestry Institute Sep 21, 2016 · The mitotic index was high in 438 patients (49%). What the mitotic index will do is to tell us how active this tissue is. So what does the mitotic index actually mean for mast cell tumors? Well, generally, a lower mitotic index is better. budset. The importance of mitosis in plants simply refers to the significance or benefits of this process in the growth and development of plants. for mitotic index determination were taken at 11 a. Jun 26, 2019 · Despite its simplicity, microscopy for detecting mitotic cells provides important information regarding malignant potential and therapeutic strategies for various tumors [5,6,7,8]. This implies that discrepancies in mitotic cell detection may affect pathologic interpretations and thus potentially patient care. 2016 Key Terms Mitotic index The ratio of the number of cells in mitosis to the total number of cells. G. 05 higher rate of MCT-related death Nov 30, 2006 · A mean correlation coefficient of 0. It is concluded that the relation between the shape of a histogram and the mitotic index of the tissue cannot be defined unless the durations of interphase and mitosis and the proportion of cells participating in the interphase-mitotic cycle are known. 00310. 8% had a mitotic rate of between 1 and 2 mitoses/mm 2, and the mitotic rate of remaining 29. M = n m/N n P. Compare the mitotic index of the two types of tumors. W. 91 (range 0. KLIMASZEWSKA4 tDepartment of Biological Sciences, Laurent/an University, Sudbury, Ontario, P3E 2C6, Petawawa National Forestry Institute Assessment and prognostic significance of mitotic index using the mitosis marker phospho-histone H3 in low and intermediate-grade infiltrating astrocytomas. The purpose of a study on dogs was to evaluate the utility of MI as a predictor of survival in dogs with cutaneous mast cell tumors (MCTs). e. This is the simplest method to indirectly determine the cell proliferation index. ( pnas. 2005;32(4):268-73. mitotic index: the ratio of cells in a tissue that are undergoing mitosis, often expressed as either the number of cells in a specified area of tissue section or as a percentage of the total cell sample. Overall, the Georgia family has a higher mitotic index, but in one study, the Virginia family had higher values in the spring. KLIMASZEWSKA4 tDepartment of Biological Sciences, Laurent/an University, Sudbury, Ontario, P3E 2C6, Petawawa National Forestry Institute 1. No patient had a node-negative disease associated with histologic Jul 11, 2018 · Well, generally, a lower mitotic index is better. Measurement of Apoptotic index (AI) and Mitotic Index (MI) was done by microscopic method only. Mitotic index and growth rate. Studies have suggested that it is an independent prognostic variable predicting survival in patients with MM, and it was recently included in the American Joint Committee on Cancer (AJCC) recommendations for diagnosis and treatment of MM. Pulse labelling of cells in the process of DNA synthesis. The meristematic region in the root tip is the actively growing region and thus the mitotic index is high. Materials and Method: The present data reveals that the mitotic index present in the leukemic-cell population in comparison to An elevated mitotic index indicates more cells are dividing. What does this information tell you about the cells in the sample? It tells us that the second on is faster in cell division. 10 ml. (e. A normal cell cycle An elevated mitotic index indicates more cells are dividing and is an important prognostic factor predicting both overall survival and response to chemotherapy in most cancer Dec 30, 2013 · Introduction Mitotic Activity Index (MAI) is an important independent prognostic factor and an integral part of the breast cancer grading system. In several tumour samples mitotic counting was difficult or impossible due to small and squeezed biopsies. (2015) Evaluating the Importance of Apoptotic Index, Mitotic Index and Turnover Index in Premalignant and Malignant Lesions of Cervix. 02(2015), Article ID:55027,8 pages 10. 12 showed a significant association between MI and overall survival, which could be important for clinical decision making Aug 08, 2013 · Mitotic index is an indication of how quickly the cells are dividing. Mitotic index (MI) is an indirect measure of cell proliferation that has been demonstrated to be a strong predictor of outcome for several human and canine cancers. PDF | In their study on canine cutaneous mast cell tumors Romansik et al (Vet Pathol 44:335-341, 2007)showed a significant association between the | Find, read and cite all the research you How to cite this paper: Bhardwaj, S. It is used to identify the sites of growth within a tissue and to determine which cell types are dividing. index (1) A statistical indicator that measures changes in the economy in general or in particular areas. Calculating Mitotic Indices. Dec 01, 2009 · Although remission rates for metastatic melanoma are generally very poor, some patients can survive for prolonged periods following metastasis. As stated above there is great within-grade variation of recurrence risk in meningioma and this was evident in our study cohort. Mitotic index helps us to quantify the cell division. The mitotic index (MI), which is defined as the sum of mitotic figures (MFs) per 10 consecutive high-power fields (HPF) in the area of the highest mitotic activity, has been Abstract. Oct 26, 2008 · The mitotic index (Mitotic Index = Number of cells in mitosis per 1000 observed cells) was determined after exposure to different dosages of MMC for different duration (Table 1). Purpose: The importance of KIT and PDGFRA mutations in the oncogenesis of gastrointestinal stromal Mitotic index 5 42 (63) >5 25 (37) AFIP risk Very low 15 (22) Sep 16, 2020 · Table 1. It is performed on conventionally stained (HE) microscopic slides. 1354/vp. Open Journal of Pathology Vol. All subjects received radiation to a dose of 70 Gy using standard technique. Prognostic tool A method of predicting the future growth of cancer cells. J Exp Bot 1998; 49:1749–1756 Google Scholar Teutonico R. In general, MI correlates with tumor grade and median survival time (MST). For grade 2 mast cell tumors, the magical number to hope for is a mitotic index of 5 or less. The use of image analysis and automation for measuring mitotic index in apical conifer meristems. Apr 13, 2021 · More cell division, faster growth, higher mitotic index. That means gradual decrease in cell division as move from the zone of cell division to the zone of cell elongation. The significance of the mitotic index in relation to interphase processes is also considered. An expression of the number of mitoses found in a stated number of cells. A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species. Careful examination of tissue secretions made from tissues and organs from cancer patients, allows the pathologist, from a count of the number of cells in mitosis, to determine, or at least estimate, how fas Heredity73 (1994) 11—17 Received 8 November 1993 Genetical Society of Great Britain Karyotype analysis and optimization of mitotic index in Picea mariana (black spruce) preparations from seedling root tips and embryogenic cultures K. 52005. index help us to quantify the cell division. Mitosis. The mitotic index was shown to be a very important prognostic factor in the present study, but it was not observed in patients classified as T1. 72 times higher rate of MCT-related death • As compared to MC = 0, MC > 4 associated with: – 36. Nov 01, 2009 · Mitotic index results should be reported on a continuous scale in addition to tertial results. 2. 2% of cases (when the mitotic index scores would have resulted in different multivariate prognostic index estimates, based on mitotic index, tumour size and lymph node status). Mitotic Index Mast Cell Tumor. 1 per cent as in thyroid, liver, and kidney epithelium (primary Nov 30, 2006 · A mean correlation coefficient of 0. The virtual lab: The Cell Cycle and Cancer 2. 183 mm2. 7mm2 then no adjuvant therapy, whereas patients with MAI ≥10/1,7mm2 should be given chemotherapy and/or additional hormonal therapy depending on the status of its steroid hormone receptors [8]. Failure to obtain clear margins during surgery. and mitotic index (MAI = mitotic activity index) <10/1. 5% of melanomas was 3 or more mitoses/mm 2. 59 times higher risk of local recurrence – 3. 0303-6987. Mitosis in this case is simply the process of cell division. Mitosis occurs in somatic cells of plants and animals. Jul 11, 2018 · Well, generally, a lower mitotic index is better. doi: 10. An adjustable-rate mortgage might begin with an interest rate of 6 percent and provide that it will increase or decrease in a like percentage as the . Part 1. 2053 The HCS Mitotic Index Kit allows for the measurement of mitotic cells using automated imaging and analysis, and is amenable to combination with other measurements such as DNA profiling, general cytotoxicity, or immunocytochemical detection of choice targets. DOI: 10. In cancer cells, the mitotic index may be elevated compared to normal growth of tissues or cellular repair of the site of an injury. The importance of the mitotic index (MI) as a prognostic factor in veterinary oncology has been emphasized recently. In addition, mitotic index has been incorporated in the American Joint Committee on Cancer (AJCC) seventh tumor staging system for malignant melanoma, gastrointestinal tumor, and neuroendocrine tumors of the gastrointestinal tract [10]. , Orr J. Design. The current mitotic index (MI) range for atypical meningiomas is broad, comprising all tumors with >4 and <20 mitotic count per 10 high-power fields, leading to substantial within-grade variation of recurrence risk, especially in borderline histologic cases, creating discordance between the clinical course and the application of the Nov 30, 2006 · A mean correlation coefficient of 0. 46-2-362. You counted mitotic cells in 8 treatment and 8 control roots, and then calculated a Mitotic Index (M) for each sample. Evaluating the Importance of Apoptotic Index, Mitotic Index and Turnover Index in Premalignant and Malignant Lesions of Cervix The mitotic index (percentage of cells in mitosis at any time) provides a measure of the capacity of cells to divide and of the rate of cell division. of cells in the dividing phase to the total number of cells observed. 2% showed better response to radical Jun 26, 2019 · Despite its simplicity, microscopy for detecting mitotic cells provides important information regarding malignant potential and therapeutic strategies for various tumors [5,6,7,8]. 001). • Abstract. Dec 17, 2008 · The Oncologist is committed to helping physicians excel in the constantly changing fields of oncology and hematology through the publication of timely reviews, original studies, and commentaries on important developments. 4236/ojpathology. In rapidly-proliferating cell populations the MI can be as high as 10 per cent, and in slowly proliferating populations the MI can be extremely low, down to at most about 0. number of dividing cells) The mitotic index will be elevated during growth and repair processes and acts as a prognostic tool for cancer Mitotic Index = *Mitotic cells have no nucleus and have visible chromosomes Cells in mitosis* The mitotic index was shown to be a very important prognostic factor in the present study, but it was not observed in patients classified as T1. Answer (1 of 2): The mitotc index is used often in the diagnosis and treatment of cancer. D. Nov 01, 2009 · —Mitotic index (MI) was defined as the mitotic cell count per 10 high-power fields (HPFs), an area 0. One of the reasons for the mitotic Mitotic count (previously referred to as “mitotic index”) • As compared to MC = 0, MC > 0 but < 4 associated with: – 5. The percentage of cells undergoing mitosis or it is defined as the ratio of no. Compare the procedure used to study mast cell cancer in dogs to the procedure you used to gather. m. A. Navigate to . M = n m/N n Sep 21, 2016 · Purpose To validate the independent strong prognostic value of mitotic activity index (MAI) in lymph node (LN) –negative invasive breast cancer patients younger than 55 years in a nationwide multicenter prospective study. In large antral follicles, mitotic index was higher (P < 0. org) Counted mitotic figures 1. It is commonly measured in fixed and stained specimens, and therefore represents the stage of the material at the time of fixing only. MI evaluation is done in the area of the tumor with highest mitotic activity. 96) was obtained. The cells exposed to concentration 2. , Binns A. N. Mitotic Index and Mitotic Phase Indices Your mitotic cell counts comprise a survey of the number of different stages of mitosis in your two populations (treatment and control). 2009 Mar;46(2):362-4, author reply 364-5. Based on mitotic index data, growth rate (µm/d) was estimated dividing the large antral follicles in subgroups according follicular diameter, i. The mitotic checkpoint, also known as the spindle assembly checkpoint, is the major cell cycle checkpoint acting during mitosis to prevent aneuploidy and CIN (reviewed in refs. No patient had a node-negative disease associated with histologic Assessment and prognostic significance of mitotic index using the mitosis marker phospho-histone H3 in low and intermediate-grade infiltrating astrocytomas Howard Colman, Caterina Giannini, Li Huang, Javier Gonzalez, Kenneth Hess, Janet Bruner, Gregory Fuller, Lauren Langford, Christopher Pelloski, Joann Aaron, Peter Burger, Ken Aldape Jul 15, 2006 · Mitotic index was assessed by direct visualization of DAPI (4′,6-diamidino-2-phenylindole)–stained cells under a fluorescence microscope. Using the mitotic index as a prognostic tool in cancer therapy. The importance of examining mitotic index in breast Nov 30, 2006 · A mean correlation coefficient of 0. Two to 6 replicate sets of 10 HPFs were counted from 328 invasive breast carcinomas. data on onion cell mitosis. An example is the cost-of-living index. According to our analysis, we found significant variations before and after neoadjuvant chemotherapy only for cyclin D1 and the mitotic index. Results: Apoptotic Index, Mitotic Index and MIB-1 expression were found to increase as the grade of lesion increased from cervical dysplasia to invasive cervical carcinoma. 001) and negative hormone receptor status (P < . Mitotic Index. Characteristics did not differ between chemotherapy and observation arms, whatever the mitotic index . 81 to 0. indication of mitotic progression or inhibition within the context of drug profiling. 05 No. 7% of the melanomas had a mitotic rate of less than 1/mm 2; 28. The more cells that are dividing, the more aggressive a given tumor is generally. Mitosis is a process through which chromosomes are split during cell division, to form other cells. Risk Stratification of Primary GIST by Mitotic Index, Tumor Size, and Tumor Location a; Mitotic Index, hpf Size, cm Site and Risk of Progressive Disease (%) GIST = gastrointestinal stromal tumors; hpf = high-power field, assessed from an area that on initial screen appears to have the highest mitotic activity. It takes place in the eukaryotic cells. Heredity73 (1994) 11—17 Received 8 November 1993 Genetical Society of Great Britain Karyotype analysis and optimization of mitotic index in Picea mariana (black spruce) preparations from seedling root tips and embryogenic cultures K. Mar 04, 2021 · The mitotic index is used for tumor grading of breast and ovarian cancers [8,9]. Aug 11, 2012 · The mitotic rate (MR) of malignant melanoma (MM) refers to the number of mitoses per square millimeter. Oct 01, 2014 · The mitotic rate ranged from 0 to 75 mitoses/mm 2 (eTable in the Supplement): 41. and Wani, F. Nov 30, 2006 · A mean correlation coefficient of 0. A normal cell cycle An elevated mitotic index indicates more cells are dividing and is an important prognostic factor predicting both overall survival and response to chemotherapy in most cancer How to cite this URL: Singh P, Kumar V, Singh G, Singh A, Singh A. 44% (40/90) cases. In addition, menopausal patients with hormone receptor–positive tumors received tamoxifen for 5 years. —Mitotic index (MI) was defined as the mitotic cell count per 10 high-power fields (HPFs), an area 0. Mitotic index decreases with increasing distance from root tip. Dec 30, 2013 · Introduction Mitotic Activity Index (MAI) is an important independent prognostic factor and an integral part of the breast cancer grading system. g. Results: Patients with Apoptotic Index (AI) less than median value of 0. , Lynn D. A mitotic index of <1/mm2 means that very few cells in the sample were actively dividing. The aim of this study was to validate the use of high resolution Whole Slide Images (WSI) in estimating MAI Apr 13, 2021 · More cell division, faster growth, higher mitotic index. e70 May 01, 2007 · Mitotic index (MI) is an indirect measure of cell proliferation that has been demonstrated to be a strong predictor of outcome for several human and canine cancers. More cell division, faster growth, higher mitotic index. Apoptotic Index and Mitotic Index were calculated on H & E stained sections in all the 90 cases while ki-67 immunostaining was done only on 44. In fed goats, the B. , dividing very rapidly). Jul 05, 2018 · Mitosis: mitotic cell division, stages and significance. Differences in mitotic index were observed between families in all three studies. 05µg/ml MMC for 24 hours (subgroup B1) was not sufficient to induce mitotic inhibition. 2% showed better response to radical Assessment and prognostic significance of mitotic index using the mitosis marker phospho-histone H3 in low and intermediate-grade infiltrating astrocytomas Howard Colman, Caterina Giannini, Li Huang, Javier Gonzalez, Kenneth Hess, Janet Bruner, Gregory Fuller , Lauren Langford, Christopher Pelloski, Joann Aaron, Peter Burger, Ken Aldape I. The exposure of 0. diameters of 350, 600 and 850 µm . Thus, we counted mitotic figures and budset. 183 mm 2. 1111/j. by Howard Colman, Caterina Giannini, Li Huang, Javier Gonzalez, Kenneth Hess, Janet Bruner, Gregory Fuller, Lauren Langford, Christopher Pelloski, Joann Aaron, Peter Burger, Ken Aldape. Significance of the apoptotic index, mitotic index, and turnover index in premalignant and malignant squamous cell lesion of the oral cavity: How much is their diagnostic and prognostic role?. K. mitotic index) To do: 1. of a 1 mc/ml. A prognostically relevant discrepancy was observed in 7. solution of Mitotic Index The mitotic index is a measure of the proliferative status of a cell population (i. KLIMASZEWSKA4 tDepartment of Biological Sciences, Laurent/an University, Sudbury, Ontario, P3E 2C6, Petawawa National Forestry Institute The mitotic index (MI), which is defined as the sum of mitotic figures (MFs) per 10 consecutive high-power fields (HPF) in the area of the highest mitotic activity, has been Jun 18, 2015 · Anatomic Pathology / PHH3 AND MITOTIC INDEX IN MENINGIOMASPrognostic Significance of the Mitotic Index Using theMitosis Marker Anti–Phosphohistone H3 in MeningiomasYoo-Jin Kim, MD,1 Ralf Ketter, MD,2 Wolf-Ingo Steudel, MD,2 and Wolfgang Feiden, MD1Key Words: Meningioma grading; Recurrence; Phosphohistone H3; PHH3; Mitosis; Ki-67DOI: 10. 5, 12– 14 In their interesting exploratory study on canine cutaneous mast cell tumors, Romansik et al. (2) A reference point against which measurements are taken for purposes of making future adjustments. Background: Mitotic index is a measure for the proliferation status of a cell population. In zero-gravity, the gravity sensing cells in the root cap are unable to send the proper orientation signals. Both families tended to reach a minimwn level of mitotic index at the same time (mid-to late December). KLIMASZEWSKA4 tDepartment of Biological Sciences, Laurent/an University, Sudbury, Ontario, P3E 2C6, Petawawa National Forestry Institute Mitotic Index The mitotic index is a measure of the proliferative status of a cell population (i. 2015. , Dudley M. KLIMASZEWSKA4 tDepartment of Biological Sciences, Laurent/an University, Sudbury, Ontario, P3E 2C6, Petawawa National Forestry Institute Assessment and prognostic significance of mitotic index using the mitosis marker phospho-histone H3 in low and intermediate-grade infiltrating astrocytomas Howard Colman, Caterina Giannini, Li Huang, Javier Gonzalez, Kenneth Hess, Janet Bruner, Gregory Fuller , Lauren Langford, Christopher Pelloski, Joann Aaron, Peter Burger, Ken Aldape I. 0